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PMID: 2448876 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

The CD14 monocyte differentiation antigen maps to a region encoding growth factors and receptors.

Science (New York, N.Y.) ·Vol. 239 ·No. 4839 ·1988-01-29 ·Pages 497-500

Goyert SM, Ferrero E, Rettig WJ, Yenamandra AK, Obata F, Le Beau MM

Abstract

CD14 is a myelomonocytic differentiation antigen expressed by monocytes, macrophages, and activated granulocytes and is detectable with the monoclonal antibodies MO2, MY4, and LeuM3. Analyses of complementary DNA and genomic clones of CD14 show that it has a novel structure and that it maps to chromosome 5 within a region containing other genes encoding growth factors and receptors; it may therefore represent a new receptor important for myeloid differentiation. In addition, the CD14 gene is included in the "critical" region that is frequently deleted in certain myeloid leukemias.

MeSH Terms

Animals Antibodies, Monoclonal Antigens, Differentiation/genetics,immunology Cell Differentiation Chromosome Mapping Chromosomes, Human, Pair 5 DNA/genetics Electrophoresis, Polyacrylamide Gel Granulocytes/immunology Growth Substances/genetics Humans Immunosorbent Techniques Leukemia/genetics Lipopolysaccharide Receptors Macrophages/immunology Mice Monocytes/immunology Myelodysplastic Syndromes/genetics Nucleic Acid Hybridization RNA, Messenger/genetics Receptors, Cell Surface/genetics

Chemicals

Antibodies, Monoclonal Antigens, Differentiation Growth Substances Lipopolysaccharide Receptors RNA, Messenger Receptors, Cell Surface DNA

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Goyert S M

Department of Rheumatic Diseases, Hospital for Joint Diseases Orthopaedic Institute, New York, NY 10003.

Ferrero E

Rettig W J

Yenamandra A K

Obata F

Le Beau M M

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.2448876

Published

1988-01-29

Pages

497-500

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NIAID NIH HHS · R01-AI23859 · United States

External Links

PubMed source DOI: 10.1126/science.2448876 View journal details

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The CD14 monocyte differentiation antigen maps to a region encoding growth factors and receptors.

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