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PMID: 2448603 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

An altered form of pp60c-src is expressed primarily in the central nervous system.

Molecular and cellular biology ·Vol. 7 ·No. 11 ·1987-11-00 ·Pages 4115-7

Le Beau JM, Wiestler OD, Walter G

Abstract

The expression of two forms of pp60c-src, pp60 and pp60+, was measured in the central nervous system (CNS) and the peripheral nervous system. Both forms were expressed in the CNS, whereas only pp60 was primarily detected in the peripheral nervous system. Our findings suggest that pp60+ may play a role in events important to the CNS.

MeSH Terms
Animals Brain/enzymology Organ Specificity Peripheral Nerves/enzymology Protein Kinases/genetics Proto-Oncogene Proteins/analysis,genetics Proto-Oncogene Proteins pp60(c-src) Rats Rats, Inbred Strains Spinal Cord/enzymology
Chemicals
Proto-Oncogene Proteins Protein Kinases Proto-Oncogene Proteins pp60(c-src)
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Le Beau J M
Department of Pathology, University of California, San Diego, La Jolla 92093.
Wiestler O D
Walter G
References (11)
11 references, click to expand
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  3. Accumulation of c-src mRNA is developmentally regulated in embryonic neural retina.
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  4. pp60c-src is developmentally regulated in the neural retina.
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    Cancer Res. 1983 Apr;43(4):1696-702 PMID: 6403227
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    Am J Pathol. 1985 Apr;119(1):151-7 PMID: 2580441
  7. Increased pp60c-src tyrosyl kinase activity in human neuroblastomas is associated with amino-terminal tyrosine phosphorylation of the src gene product.
    Proc Natl Acad Sci U S A. 1985 Nov;82(21):7275-9 PMID: 2414774
  8. Localization of conserved and nonconserved epitopes within the Rous sarcoma virus-encoded src protein.
    J Virol. 1986 Sep;59(3):755-8 PMID: 2426472
  9. pp60c-src in the developing cerebellum.
    Mol Cell Biol. 1985 Jan;5(1):27-32 PMID: 3920510
  10. Neurones express high levels of a structurally modified, activated form of pp60c-src.
    Nature. 1985 Aug 8-14;316(6028):554-7 PMID: 2412121
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    J Virol. 1983 Nov;48(2):352-60 PMID: 6312092
Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.7.11.4115-4117.1987
Published
1987-11-00
Pages
4115-7
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC368082
Subset
IM
Grants
NINDS NIH HHS · NS07078-10 · United States
External Links
PubMed source DOI: 10.1128/mcb.7.11.4115-4117.1987 PMC Full Text View journal details
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