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题目:: Mevalonate metabolism in cancer.
作者:: Gruenbacher(Georg),Thurnher(Martin)
状态:: 发布时间2014-12-01 , 更新时间 2014-12-01
期刊:: Cancer Lett
摘要:: Cancer cells are characterized by sustained proliferative signaling, insensitivity to growth suppressors and resistance to apoptosis as well as by replicative immortality, the capacity to induce angiogenesis and to perform invasive growth. Additional hallmarks of cancer cells include the reprogramming of energy metabolism as well as the ability to evade immune surveillance. The current review focuses on the metabolic reprogramming of cancer cells and on the immune system's capacity to detect such changes in cancer cell metabolism. Specifically, we focus on mevalonate metabolism, which is a target for drug and immune based cancer treatment.
语言:: eng
DOI:: 10.1016/j.canlet.2014.01.013

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