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PMID: 24413322 Published · ppublish English Letter Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

WTAP is a novel oncogenic protein in acute myeloid leukemia.

Leukemia ·Vol. 28 ·No. 5 ·2014-05-00 ·Pages 1171-4

Bansal H, Yihua Q, Iyer SP, Ganapathy S, Proia DA, Proia D, Penalva LO, Uren PJ, Suresh U, Carew JS, Karnad AB, Weitman S, Tomlinson GE, Rao MK, Kornblau SM, Bansal S

Abstract

暂无摘要

MeSH Terms

Cell Cycle Proteins Humans Leukemia, Myeloid, Acute/genetics,pathology Nuclear Proteins/genetics RNA Splicing Factors

Chemicals

Cell Cycle Proteins Nuclear Proteins RNA Splicing Factors WTAP protein, human

Authors & Affiliations

16 authors, click to expand affiliations / ORCID

Bansal H

Greehey Children's Cancer Research Institute, The University of Texas Health Science Center, San Antonio, TX, USA.

Yihua Q

Department of Leukemia & Department of Stem Cell Transplantation and Cellular Therapy, The MD Anderson Cancer Center, Houston, TX, USA.

Iyer S P

Methodist Cancer Center, Houston, TX, USA.

Ganapathy S

Greehey Children's Cancer Research Institute, The University of Texas Health Science Center, San Antonio, TX, USA.

Proia D A

Proia D

Synta Pharmaceuticals Corp, Lexington, MA, USA.

Penalva L O

1] Greehey Children's Cancer Research Institute, The University of Texas Health Science Center, San Antonio, TX, USA [2] Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, TX, USA.

Uren P J

Division of Biological Sciences at University of Southern California, Los Angeles, CA, USA.

Suresh U

Greehey Children's Cancer Research Institute, The University of Texas Health Science Center, San Antonio, TX, USA.

Carew J S

Institute for Drug Development, Cancer Therapy and Research Center, The University of Texas Health Science Center, San Antonio, TX, USA.

Karnad A B

Department of Medicine, The University of Texas Health Science Center, San Antonio, TX, USA.

Weitman S

Institute for Drug Development, Cancer Therapy and Research Center, The University of Texas Health Science Center, San Antonio, TX, USA.

Tomlinson G E

Greehey Children's Cancer Research Institute, The University of Texas Health Science Center, San Antonio, TX, USA.

Rao M K

Kornblau S M

Department of Leukemia & Department of Stem Cell Transplantation and Cellular Therapy, The MD Anderson Cancer Center, Houston, TX, USA.

Bansal S

Greehey Children's Cancer Research Institute, The University of Texas Health Science Center, San Antonio, TX, USA.

References (17)

17 references, click to expand

Vascular biology and the sex of flies: regulation of vascular smooth muscle cell proliferation by wilms' tumor 1-associating protein.
Trends Cardiovasc Med. 2007 Oct;17(7):230-4 PMID: 17936204
HSP90 and the chaperoning of cancer.
Nat Rev Cancer. 2005 Oct;5(10):761-72 PMID: 16175177
Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA.
Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17278-83 PMID: 17088532
Ganetespib, a unique triazolone-containing Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile for cancer therapy.
Mol Cancer Ther. 2012 Feb;11(2):475-84 PMID: 22144665
Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia.
Haematologica. 2010 May;95(5):819-28 PMID: 19951971
Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein.
Proc Natl Acad Sci U S A. 1988 Dec;85(23):9312-6 PMID: 3143116
Acute myeloid leukaemia.
Lancet. 2006 Nov 25;368(9550):1894-907 PMID: 17126723
Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin.
J Biol Chem. 1996 Sep 13;271(37):22796-801 PMID: 8798456
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.
N Engl J Med. 2013 May 30;368(22):2059-74 PMID: 23634996
The Drosophila fl(2)d gene, required for female-specific splicing of Sxl and tra pre-mRNAs, encodes a novel nuclear protein with a HQ-rich domain.
Genetics. 2000 May;155(1):129-39 PMID: 10790389
Identification of WTAP, a novel Wilms' tumour 1-associating protein.
Hum Mol Genet. 2000 Sep 22;9(15):2231-9 PMID: 11001926
Drug therapy for acute myeloid leukemia.
Blood. 2005 Aug 15;106(4):1154-63 PMID: 15870183
Heat shock protein 90 regulates the expression of Wilms tumor 1 protein in myeloid leukemias.
Blood. 2010 Nov 25;116(22):4591-9 PMID: 20651072
Transcription factors in myeloid development: balancing differentiation with transformation.
Nat Rev Immunol. 2007 Feb;7(2):105-17 PMID: 17259967
HDAC6 inhibition enhances 17-AAG--mediated abrogation of hsp90 chaperone function in human leukemia cells.
Blood. 2008 Sep 1;112(5):1886-93 PMID: 18591380
Expression and roles of Wilms' tumor 1-associating protein in glioblastoma.
Cancer Sci. 2012 Dec;103(12):2102-9 PMID: 22957919
WT1 (Wilms' tumor gene 1): biology and cancer immunotherapy.
Jpn J Clin Oncol. 2010 May;40(5):377-87 PMID: 20395243

Article Info

Journal

Leukemia

Abbr.

Leukemia

ISSN

1476-5551

DOI

10.1038/leu.2014.16

Published

2014-05-00

Epub

2014-00-13

Pages

1171-4

Language

English

Region

England

NLM ID

8704895

PMCID

PMC4369791

Subset

Grants

NCI NIH HHS · P30 CA016672 · United States

NCI NIH HHS · CA054174 · United States

NCI NIH HHS · P30 CA054174 · United States

NICHD NIH HHS · HD057118 · United States

NICHD NIH HHS · R01 HD057118 · United States

Corrections

ErratumIn

External Links

PubMed source DOI: 10.1038/leu.2014.16 PMC Full Text View journal details

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