LC3-associated phagocytosis.

Autophagy ·Vol. 10 ·No. 3 ·2014-03-00 ·Pages 526-8

Romao S, Münz C

Abstract

A recent report from our group has described that upon engulfment of pathogens, a subset of phagosomes is formed to preserve antigens for prolonged presentation on MHC class II molecules. The distinctive feature of these particular vesicles is their coating with LC3/Atg8, a key component of the autophagy machinery. Here we discuss the possible outcomes of LC3-associated phagocytosis and its implications in the context of immunity.

Keywords

Atg8/LC3 MHC class II macroautophagy phagocytosis phagosomal maturation

MeSH Terms

Adaptor Proteins, Signal Transducing/immunology Animals Antigen Presentation/immunology Autophagy/immunology Histocompatibility Antigens Class II/immunology Humans Microtubule-Associated Proteins/immunology Phagosomes/immunology

Chemicals

Adaptor Proteins, Signal Transducing Histocompatibility Antigens Class II Microtubule-Associated Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Romao Susana

Viral Immunobiology; Institute of Experimental Immunology; University of Zürich; Zürich, Switzerland.

Münz Christian

Viral Immunobiology; Institute of Experimental Immunology; University of Zürich; Zürich, Switzerland.

Article Info

Journal

Autophagy

Abbr.

Autophagy

ISSN

1554-8635

DOI

10.4161/auto.27606

Published

2014-03-00

Epub

2014-00-07

Pages

526-8

Language

English

Region

United States

NLM ID

101265188

PMCID

PMC4077893

Subset

External Links

PubMed source DOI: 10.4161/auto.27606 PMC Full Text View journal details

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LC3-associated phagocytosis.

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