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PMID: 2437974 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Why is gramicidin valence selective? A theoretical study.

Biophysical journal ·Vol. 51 ·No. 4 ·1987-04-00 ·Pages 661-72

Sung SS, Jordan PC

Abstract

Calculations contrasting the channel solvation energy for cesium ions and chloride ions associated with water in gramicidin-like channels are presented. The energy profile for the cation exhibits a deep well at the channel entrance; within the single file region the solvation energy is roughly constant. The anion exhibits a totally different energy profile. There is an energy barrier at the channel entrance; if the ion could surmount this barrier, it would be quite stable within the channel. At the channel entrance, the calculated solvation energy difference between anion and cation is approximately 15 kcal mol-1. This is completely consistent with the observation that chloride neither permeates nor blocks the channel since the estimated rate of ion entry would be approximately 0.01-10(-5) s-1, far slower than the rate at which the channel dimer dissociates into monomers.

MeSH Terms
Cesium Chlorides Gramicidin Ion Channels/physiology Models, Biological Protein Conformation Thermodynamics
Chemicals
Chlorides Ion Channels Gramicidin Cesium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Sung S S
Jordan P C
References (23)
23 references, click to expand
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Article Info
Journal
Biophysical journal
Abbr.
Biophys J
ISSN
0006-3495
DOI
10.1016/S0006-3495(87)83391-X
Published
1987-04-00
Pages
661-72
Language
English
Region
United States
NLM ID
0370626
PMCID
PMC1329938
Subset
IM
Grants
NIGMS NIH HHS · GM-28643 · United States
External Links
PubMed source DOI: 10.1016/S0006-3495(87)83391-X PMC Full Text View journal details
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