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PMID: 24352663 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

miR-185 is an independent prognosis factor and suppresses tumor metastasis in gastric cancer.

Molecular and cellular biochemistry ·Vol. 386 ·No. 1-2 ·2014-01-00 ·Pages 223-31

Tan Z, Jiang H, Wu Y, Xie L, Dai W, Tang H, Tang S

Abstract

miR-185 has been identified as an important factor in several cancers such as breast cancer, ovarial cancer, and prostate cancer. However, its effect and prognostic value in gastric cancer are still poorly known. In this study, we found that the expression levels of miR-185 were strongly downregulated in gastric cancer and associated with clinical stage and the presence of lymph node metastases. Moreover, miR-185 might independently predict OS and RFS in gastric cancer. We further found that upregulation of miR-185 inhibited the proliferation and metastasis of gastric cancer cells in vitro and in vivo. Taken together, our findings demonstrate that the miR-185 is important for gastric cancer initiation and progression and holds promise as a prognostic biomarker to predict survival and relapse in gastric cancer. It is also a potential therapeutic tool to improve clinical outcomes in the above disease.

MeSH Terms
Adult Aged Animals Base Sequence Biomarkers, Tumor/metabolism Cell Line DNA Primers Female Heterografts Humans In Situ Hybridization Male Mice MicroRNAs/physiology Middle Aged Neoplasm Metastasis/genetics Prognosis Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Stomach Neoplasms/genetics,pathology
Chemicals
Biomarkers, Tumor DNA Primers MIRN185 microRNA, human MicroRNAs
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Tan Zhiqin
Center for Gastric Cancer Research of Human Province, The First Affiliated Hospital, University of South China, 69 Chuanshan Road, Hengyang, 421001, People's Republic of China, tzq169@163.com.
Jiang Hao
Wu Youhua
Xie Liming
Dai Wenxiang
Tang Hailin
Tang Sanyuan
References (31)
31 references, click to expand
  1. miR-185 and miR-133b deregulation is associated with overall survival and metastasis in colorectal cancer.
    Int J Oncol. 2011 Aug;39(2):311-8 PMID: 21573504
  2. Overexpression of miR-370 and downregulation of its novel target TGFβ-RII contribute to the progression of gastric carcinoma.
    Oncogene. 2012 Jan 12;31(2):226-37 PMID: 21666718
  3. Metastamir: the field of metastasis-regulatory microRNA is spreading.
    Cancer Res. 2009 Oct 1;69(19):7495-8 PMID: 19773429
  4. MicroRNA-148a suppresses tumor cell invasion and metastasis by downregulating ROCK1 in gastric cancer.
    Clin Cancer Res. 2011 Dec 15;17(24):7574-83 PMID: 21994419
  5. LRRC4 inhibits glioma cell growth and invasion through a miR-185-dependent pathway.
    Curr Cancer Drug Targets. 2012 Oct;12(8):1032-42 PMID: 22834685
  6. MiR-152 and miR-185 co-contribute to ovarian cancer cells cisplatin sensitivity by targeting DNMT1 directly: a novel epigenetic therapy independent of decitabine.
    Oncogene. 2014 Jan 16;33(3):378-86 PMID: 23318422
  7. MicroRNA-185 suppresses proliferation, invasion, migration, and tumorigenicity of human prostate cancer cells through targeting androgen receptor.
    Mol Cell Biochem. 2013 May;377(1-2):121-30 PMID: 23417242
  8. MiR-107 and MiR-185 can induce cell cycle arrest in human non small cell lung cancer cell lines.
    PLoS One. 2009 Aug 18;4(8):e6677 PMID: 19688090
  9. MiR-185 targets the DNA methyltransferases 1 and regulates global DNA methylation in human glioma.
    Mol Cancer. 2011 Sep 30;10:124 PMID: 21962230
  10. Autoregulatory suppression of c-Myc by miR-185-3p.
    J Biol Chem. 2011 Sep 30;286(39):33901-9 PMID: 21832077
  11. Clinical significance of miR-146a in gastric cancer cases.
    Clin Cancer Res. 2011 Jul 1;17(13):4277-84 PMID: 21632853
  12. MicroRNAs: novel biomarkers for human cancer.
    Clin Chem. 2009 Apr;55(4):623-31 PMID: 19246618
  13. miR-214 promotes tumorigenesis by targeting lactotransferrin in nasopharyngeal carcinoma.
    Tumour Biol. 2013 Jun;34(3):1793-800 PMID: 23479198
  14. miR-429 modulates the expression of c-myc in human gastric carcinoma cells.
    Eur J Cancer. 2011 Nov;47(17):2552-9 PMID: 21684154
  15. Genomic loss of miR-486 regulates tumor progression and the OLFM4 antiapoptotic factor in gastric cancer.
    Clin Cancer Res. 2011 May 1;17(9):2657-67 PMID: 21415212
  16. MicroRNA-107, an oncogene microRNA that regulates tumour invasion and metastasis by targeting DICER1 in gastric cancer.
    J Cell Mol Med. 2011 Sep;15(9):1887-95 PMID: 21029372
  17. MicroRNAs and cancer: short RNAs go a long way.
    Cell. 2009 Feb 20;136(4):586-91 PMID: 19239879
  18. MicroRNA-185 suppresses tumor growth and progression by targeting the Six1 oncogene in human cancers.
    Oncogene. 2010 Sep 2;29(35):4971-9 PMID: 20603620
  19. The miR-183/96/182 cluster regulates oxidative apoptosis and sensitizes cells to chemotherapy in gliomas.
    Curr Cancer Drug Targets. 2013 Feb;13(2):221-31 PMID: 23252827
  20. MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death.
    Oncogene. 2008 Oct 6;27(45):5959-74 PMID: 18836476
  21. Gastric cancer.
    Lancet. 2009 Aug 8;374(9688):477-90 PMID: 19625077
  22. MicroRNA in cancer prognosis.
    N Engl J Med. 2008 Dec 18;359(25):2720-2 PMID: 19092157
  23. MiR-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor.
    PLoS Genet. 2010 Mar 12;6(3):e1000879 PMID: 20300657
  24. Metastasis-related miR-185 is a potential prognostic biomarker for hepatocellular carcinoma in early stage.
    Biomed Pharmacother. 2013 Jun;67(5):393-8 PMID: 23648054
  25. miR-185 targets RhoA and Cdc42 expression and inhibits the proliferation potential of human colorectal cells.
    Cancer Lett. 2011 Feb 28;301(2):151-60 PMID: 21186079
  26. Survival prediction of gastric cancer by a seven-microRNA signature.
    Gut. 2010 May;59(5):579-85 PMID: 19951901
  27. Lymph nodes and gastric cancer.
    J Surg Oncol. 2009 Mar 15;99(4):199-206 PMID: 19142901
  28. miR-200b and miR-200c as prognostic factors and mediators of gastric cancer cell progression.
    Clin Cancer Res. 2013 Oct 15;19(20):5602-12 PMID: 23995857
  29. Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world.
    J Clin Oncol. 2006 May 10;24(14):2137-50 PMID: 16682732
  30. Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis.
    Lancet Oncol. 2010 Feb;11(2):136-46 PMID: 20022810
  31. MicroRNA-125a-5p is an independent prognostic factor in gastric cancer and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab.
    Clin Cancer Res. 2011 May 1;17(9):2725-33 PMID: 21220473
Article Info
Journal
Molecular and cellular biochemistry
Abbr.
Mol Cell Biochem
ISSN
1573-4919
DOI
10.1007/s11010-013-1860-y
Email
tzq169@163.com
Published
2014-01-00
Epub
2013-00-25
Pages
223-31
Language
English
Region
Netherlands
NLM ID
0364456
Subset
IM
External Links
PubMed source DOI: 10.1007/s11010-013-1860-y View journal details
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