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PMID: 2434887 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Evidence for galanin as an inhibitory neuropeptide on myenteric cholinergic neurons in the guinea pig small intestine.

Neuroscience letters ·Vol. 72 ·No. 3 ·1986-12-23 ·Pages 305-8

Yau WM, Dorsett JA, Youther ML

Abstract

The effect of galanin on the [3H]ACh release from myenteric plexus-longitudinal muscle strips of the guinea pig small intestine was studied. While galanin did not alter the basal spontaneous efflux of ACh, it significantly depressed the ACh release evoked by electrical stimulation or caused by VIP and substance P. These results suggest an important neuromodulatory role for galanin in the enteric nervous system.

MeSH Terms

Acetylcholine/metabolism Animals Cholinergic Fibers/drug effects,physiology Cholinesterase Inhibitors Electric Stimulation Galanin Guinea Pigs In Vitro Techniques Intestine, Small/drug effects,innervation Myenteric Plexus/drug effects,physiology Peptides/pharmacology Substance P/pharmacology Vasoactive Intestinal Peptide/pharmacology

Chemicals

Cholinesterase Inhibitors Peptides Substance P Vasoactive Intestinal Peptide Galanin Acetylcholine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Yau W M

Dorsett J A

Youther M L

Article Info

Journal

Neuroscience letters

Abbr.

Neurosci Lett

ISSN

0304-3940

DOI

10.1016/0304-3940(86)90531-8

Published

1986-12-23

Pages

305-8

Language

English

Region

Ireland

NLM ID

7600130

Subset

Grants

NIADDK NIH HHS · AM-26860 · United States

External Links

PubMed source DOI: 10.1016/0304-3940(86)90531-8 View journal details

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Evidence for galanin as an inhibitory neuropeptide on myenteric cholinergic neurons in the guinea pig small intestine.

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