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PMID: 24337300 Published · ppublish English Journal Article Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

The genome of the ctenophore Mnemiopsis leidyi and its implications for cell type evolution.

Science (New York, N.Y.) ·Vol. 342 ·No. 6164 ·2013-12-13 ·Pages 1242592

Ryan JF, Pang K, Schnitzler CE, Nguyen AD, Moreland RT, Simmons DK, Koch BJ, Francis WR, Havlak P, NISC Comparative Sequencing Program, Smith SA, Putnam NH, Haddock SH, Dunn CW, Wolfsberg TG, Mullikin JC, Martindale MQ, Baxevanis AD

Abstract

An understanding of ctenophore biology is critical for reconstructing events that occurred early in animal evolution. Toward this goal, we have sequenced, assembled, and annotated the genome of the ctenophore Mnemiopsis leidyi. Our phylogenomic analyses of both amino acid positions and gene content suggest that ctenophores rather than sponges are the sister lineage to all other animals. Mnemiopsis lacks many of the genes found in bilaterian mesodermal cell types, suggesting that these cell types evolved independently. The set of neural genes in Mnemiopsis is similar to that of sponges, indicating that sponges may have lost a nervous system. These results present a newly supported view of early animal evolution that accounts for major losses and/or gains of sophisticated cell types, including nerve and muscle cells.

MeSH Terms
Animals Base Sequence Biological Evolution Cell Lineage/genetics Ctenophora/classification,cytology,genetics Genome Mesoderm/cytology Molecular Sequence Data Muscle Development/genetics Neurogenesis/genetics Phylogeny
Authors & Affiliations
18 authors, click to expand affiliations / ORCID
Ryan Joseph F
Genome Technology Branch, Division of Intramural Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Pang Kevin
Schnitzler Christine E
Nguyen Anh-Dao
Moreland R Travis
Simmons David K
Koch Bernard J
Francis Warren R
Havlak Paul
NISC Comparative Sequencing Program
Smith Stephen A
Putnam Nicholas H
Haddock Steven H D
Dunn Casey W
Wolfsberg Tyra G
Mullikin James C
Martindale Mark Q
Baxevanis Andreas D
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Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
DOI
10.1126/science.1242592
Published
2013-12-13
Pages
1242592
Language
English
Region
United States
NLM ID
0404511
PMCID
PMC3920664
Subset
IM
Grants
Intramural NIH HHS · ZIA HG000140-13 · United States
Intramural NIH HHS · ZIA HG000140-14 · United States
Intramural NIH HHS · ZIA HG000140-15 · United States
Databases
GENBANK
AGCP00000000
Corrections
CommentIn
PMID: 24337283
CommentIn
PMID: 25137591
External Links
PubMed source DOI: 10.1126/science.1242592 PMC Full Text View journal details
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