Oral cancers are uncommon in the United States. Risk factors for oral cancer include tobacco use, alcohol consumption, and high-risk oral human papillomavirus infection. Precancerous lesions, such as leukoplakia, may lead to oral cancers, but the majority of precancerous lesions never undergo malignant transformation. Management and prognosis for oral cancers vary widely depending on the site of the cancer. Lip cancers typically are detected early and have the greatest likelihood for cure and long-term patient survival. Cancers of the pharynx and tonsil have poor survival rates even when diagnosed in early stages. The best approach to preventing oral cancers is to control risk factors.