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PMID: 24298051 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements.

Genes & development ·Vol. 27 ·No. 23 ·2013-12-01 ·Pages 2513-30

Zhang CZ, Leibowitz ML, Pellman D

Abstract

Recent genome sequencing studies have identified several classes of complex genomic rearrangements that appear to be derived from a single catastrophic event. These discoveries identify ways that genomes can be altered in single large jumps rather than by many incremental steps. Here we compare and contrast these phenomena and examine the evidence that they arise "all at once." We consider the impact of massive chromosomal change for the development of diseases such as cancer and for evolution more generally. Finally, we summarize current models for underlying mechanisms and discuss strategies for testing these models.

Keywords
cancer chromoanasynthesis chromoplexy chromosomal translocation chromothripsis copy number alteration genome evolution
MeSH Terms
Chromosome Aberrations Evolution, Molecular Gene Rearrangement/genetics Genome, Human/genetics Genomic Instability Humans
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Zhang Cheng-Zhong
Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA;
Leibowitz Mitchell L
Pellman David
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Article Info
Journal
Genes & development
Abbr.
Genes Dev
ISSN
1549-5477
DOI
10.1101/gad.229559.113
Published
2013-12-01
Pages
2513-30
Language
English
Region
United States
NLM ID
8711660
PMCID
PMC3861665
Subset
IM
Grants
Howard Hughes Medical Institute · United States
NIGMS NIH HHS · GM083299 · United States
NCI NIH HHS · U24CA143867 · United States
NIGMS NIH HHS · R01 GM083299 · United States
NCI NIH HHS · U24 CA143867 · United States
External Links
PubMed source DOI: 10.1101/gad.229559.113 PMC Full Text View journal details
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