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PMID: 24296784 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

A current perspective of autophagosome biogenesis.

Cell research ·Vol. 24 ·No. 1 ·2014-01-00 ·Pages 58-68

Shibutani ST, Yoshimori T

Abstract

Autophagy is a bulk degradation system induced by cellular stresses such as nutrient starvation. Its function relies on the formation of double-membrane vesicles called autophagosomes. Unlike other organelles that appear to stably exist in the cell, autophagosomes are formed on demand, and once their formation is initiated, it proceeds surprisingly rapidly. How and where this dynamic autophagosome formation takes place has been a long-standing question, but the discovery of Atg proteins in the 1990's significantly accelerated our understanding of autophagosome biogenesis. In this review, we will briefly introduce each Atg functional unit in relation to autophagosome biogenesis, and then discuss the origin of the autophagosomal membrane with an introduction to selected recent studies addressing this problem.

MeSH Terms
Animals Autophagy/physiology Cell Membrane/metabolism Intracellular Signaling Peptides and Proteins/metabolism Phagosomes/metabolism Protein Serine-Threonine Kinases/metabolism Starvation Vacuoles Yeasts/cytology
Chemicals
Intracellular Signaling Peptides and Proteins Protein Serine-Threonine Kinases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Shibutani Shusaku T
1] Laboratory of Intracellular Membrane Dynamics, Graduate School of Frontier Biosciences, Osaka University, Osaka 565-0871, Japan [2] Department of Genetics, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.
Yoshimori Tamotsu
1] Laboratory of Intracellular Membrane Dynamics, Graduate School of Frontier Biosciences, Osaka University, Osaka 565-0871, Japan [2] Department of Genetics, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.
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Article Info
Journal
Cell research
Abbr.
Cell Res
ISSN
1748-7838
DOI
10.1038/cr.2013.159
Published
2014-01-00
Epub
2013-00-03
Pages
58-68
Language
English
Region
England
NLM ID
9425763
PMCID
PMC3879706
Subset
IM
External Links
PubMed source DOI: 10.1038/cr.2013.159 PMC Full Text View journal details
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