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题目:: The GABAB receptor associates with regulators of G-protein signaling 4 protein in the mouse prefrontal cortex and hypothalamus.
作者:: Kim(Gyeongwha),Jung(Soonwoong),Son(Hyeonwi),Kim(Sujeong),Choi(Jungil),Lee(Dong Hoon),Roh(Gu Seob),Kang(Sang Soo),Cho(Gyeong Jae),Choi(Wan Sung),Kim(Hyun Joon)
状态:: 发布时间2014-06-25 , 更新时间 2015-04-22
期刊:: BMB Rep
摘要:: Regulators of G-protein signaling (RGS) proteins regulate certain G-protein-coupled receptor (GPCR)-mediated signaling pathways. The GABA(B) receptor (GABA(B)R) is a GPCR that plays a role in the stress response. Previous studies indicate that acute immobilization stress (AIS) decreases RGS4 in the prefrontal cortex (PFC) and hypothalamus (HY) and suggest the possibility of a signal complex composed of RGS4 and GABA(B)R. Therefore, in the present study, we tested whether RGS4 associates with GABA(B)R in these brain regions. We found the co-localization of RGS4 and GABA(B)R subtypes in the PFC and HY using double immunohistochemistry and confirmed a direct association between GABA(B2)R and RGS4 proteins using co-immunoprecipitation. Furthermore, we found that AIS decreased the amount of RGS4 bound to GABA(B2)R and the number of double-positive cells. These results indicate that GABA(B)R forms a signal complex with RGS4 and suggests that RGS4 is a regulator of GABA(B)R.
语言:: eng
DOI:

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