The effect of density on the gastric emptying of single- and multiple-unit dosage forms.

Pharmaceutical research ·Vol. 3 ·No. 4 ·1986-08-00 ·Pages 208-13

Davis SS, Stockwell AF, Taylor MJ, Hardy JG, Whalley DR, Wilson CG, Bechgaard H, Christensen FN

Abstract

The gastric emptying of pellets and single units of different densities has been followed in healthy subjects using the technique of gamma scintigraphy. The gastric emptying of the light pellets was affected by their buoyancy in the upper part of the stomach. However, the mean gastric emptying rates of pellets and single units were not significantly affected by density. Floating or buoyant delivery systems may have little advantage over conventional systems. The presence of food in the stomach was found to be the major factor in determining the gastric emptying of single units.

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Davis S S

Department of Pharmacy, University of Nottingham, Nottingham, UK.

Stockwell A F

Taylor M J

Hardy J G

Whalley D R

Wilson C G

Bechgaard H

Christensen F N

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Article Info

Journal

Pharmaceutical research

Abbr.

Pharm Res

ISSN

0724-8741

DOI

10.1023/A:1016334629169

Published

1986-08-00

Pages

208-13

Language

English

Region

United States

NLM ID

8406521

External Links

PubMed source DOI: 10.1023/A:1016334629169 View journal details

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The effect of density on the gastric emptying of single- and multiple-unit dosage forms.

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