| GeneLibs

题目:: Identification of a cancer stem cell-like side population in the HeLa human cervical carcinoma cell line.
作者:: Wang(Kefang),Zeng(Jianfang),Luo(Lijing),Yang(Jiaxin),Chen(Jie),Li(Bin),Shen(Keng)
状态:: 发布时间2013-11-21 , 更新时间 2013-11-21
期刊:: Oncol Lett
摘要:: The present study aimed to identify the stem cell characteristics of side population (SP) cells sorted from the widely-used HeLa human cervical carcinoma cell line. The SP cells were sorted from the HeLa cell line using fluorescence-activating cell sorting (FACS). Stem cell characteristics of the SP cells, including proliferation, self-renewal, differentiation and the ability to form xenografts, were investigated and . The SP cells demonstrated strong tumorigenesis following transplantation into five to six-week-old female Balb/c mice. The SP cells were observed to be more resistant to chemotherapy and radiotherapy compared with non-side population (NSP) cells. A higher expression of CD133 was observed in the SP cells compared with the NSP cells following FACS. The results demonstrated that the SP cells from the HeLa human cervical carcinoma cell line exhibit stem cell characteristics and also have a strong ability to form tumors . The cell surface marker CD133 may serve as a potential molecular marker for the identification of cervical cancer stem cells (CSCs).
语言:: eng
DOI:

文献库文献相关信息