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PMID: 2422648 Published · ppublish English Journal Article

Kinetic diagram and free energy diagram for kinesin in microtubule-related motility.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 83 ·No. 10 ·1986-05-00 ·Pages 3326-30

Hill TL

Abstract

The theoretical formalism that shows how biochemistry (ATPase activity) is related to mechanics in muscle contraction can be extended to the role of kinesin in microtubule-related motility. The main features added are the freedom of kinesin molecules to come and go from the motility complex and the small number of operative kinesin molecules in some systems. The starting points for this kind of approach are the kinetic diagram of biochemical states and the corresponding free energy diagram for these states. These topics are introduced and discussed here in relation to those systems that are presumed to use kinesin.

MeSH Terms
Adenosine Triphosphatases/metabolism Adenosine Triphosphate/metabolism Animals Axonal Transport Binding Sites Cell Movement Kinesins Kinetics Microtubules/metabolism Nerve Tissue Proteins/metabolism Thermodynamics
Chemicals
Nerve Tissue Proteins Adenosine Triphosphate Adenosine Triphosphatases Kinesins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Hill T L
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22 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.83.10.3326
Published
1986-05-00
Pages
3326-30
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC323506
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.83.10.3326 PMC Full Text View journal details
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