Adhesion properties of a neuronal epitope recognized by the monoclonal antibody HNK-1.

Brain research ·Vol. 367 ·No. 1-2 ·1986-03-05 ·Pages 20-5

Riopelle RJ, McGarry RC, Roder JC

Abstract

A carbohydrate epitope on adhesion proteins of the developing nervous system, and on myelin-associated glycoprotein, is recognized by the monoclonal antibody HNK-1. The HNK-1 epitope bearing proteins and the monoclonal antibody alter, in a dose-dependent manner, the interaction between neurons and neurite-promoting substrate-attached materials released from cultured neural cells.

MeSH Terms

Animals Antibodies, Monoclonal Antigens, Surface/immunology Cell Adhesion Molecules Cells, Cultured Chick Embryo Cross Reactions Epitopes/analysis Extracellular Matrix/immunology Ganglia, Spinal/immunology Myelin Proteins/immunology Myelin-Associated Glycoprotein Nerve Growth Factors/immunology Nervous System/immunology Spinal Cord/immunology

Chemicals

Antibodies, Monoclonal Antigens, Surface Cell Adhesion Molecules Epitopes Myelin Proteins Myelin-Associated Glycoprotein Nerve Growth Factors

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Riopelle R J

McGarry R C

Roder J C

Article Info

Journal

Brain research

Abbr.

Brain Res

ISSN

0006-8993

DOI

10.1016/0006-8993(86)91573-8

Published

1986-03-05

Pages

20-5

Language

English

Region

Netherlands

NLM ID

0045503

Subset

External Links

PubMed source DOI: 10.1016/0006-8993(86)91573-8 View journal details

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Adhesion properties of a neuronal epitope recognized by the monoclonal antibody HNK-1.

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