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题目:: Global real-time quantitative reverse transcription-polymerase chain reaction detecting proto-oncogenes associated with 14q32 chromosomal translocation as a valuable marker for predicting survival in multiple myeloma.
作者:: Inagaki(Atsushi),Tajima(Emi),Uranishi(Miyuki),Totani(Haruhito),Asao(Yu),Ogura(Hiroka),Masaki(Ayako),Yoshida(Tatsuya),Mori(Fumiko),Ito(Asahi),Yano(Hiroki),Ri(Masaki),Kayukawa(Satoshi),Kataoka(Takae),Kusumoto(Shigeru),Ishida(Takashi),Hayami(Yoshihito),Hanamura(Ichiro),Komatsu(Hirokazu),Inagaki(Hiroshi),Matsuda(Yasufumi),Ueda(Ryuzo),Iida(Shinsuke)
状态:: 发布时间2013-11-26 , 更新时间 2015-11-19
期刊:: Leuk Res
摘要:: CCND1, FGFR3 and c-MAF mRNA expression of tumor samples from 123 multiple myeloma patients were analyzed by global RQ/RT-PCR. CCND1, FGFR3 and c-MAF were positive in 44 (36%), 28 (23%) and 16 (13%) of patients, respectively. In 7 patients, both FGFR3 and c-MAF were positive. The expression of c-MAF was independent unfavorable prognostic factors for overall survival (OS). Autologous stem cell transplantation improved progression-free survival of CCND1-positive patients. Bortezomib, thalidomide or lenalidomide extended OS of FGFR3 and/or c-MAF-positive patients. Thus, CCND1, FGFR3 and c-MAF mRNA expression can predict survival and is useful for planning stratified treatment strategies for myeloma patients.
语言:: eng
DOI:: 10.1016/j.leukres.2013.09.026

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