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PMID: 24209613 Published · ppublish English Journal Article Comment

m(6)A mRNA methylation: a new circadian pacesetter.

Cell ·Vol. 155 ·No. 4 ·2013-11-07 ·Pages 740-1

Hastings MH

Abstract

The purpose of m(6)A methylation of RNA, first observed in the 1970s, has been a longstanding mystery. Fustin et al. now show that it regulates RNA processing and determines the period and oscillatory stability of the mammalian circadian clockwork.

MeSH Terms
Circadian Clocks Humans Methyltransferases/metabolism RNA/metabolism RNA Processing, Post-Transcriptional
Chemicals
RNA Methyltransferases METTL3 protein, human
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Hastings Michael H
MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK. Electronic address: mha@mrc-lmb.cam.ac.uk.
Article Info
Journal
Cell
Abbr.
Cell
ISSN
1097-4172
DOI
10.1016/j.cell.2013.10.028
Email
mha@mrc-lmb.cam.ac.uk
Published
2013-11-07
Pages
740-1
Language
English
Region
United States
NLM ID
0413066
Subset
IM
Corrections
CommentOn
PMID: 24209618
External Links
PubMed source DOI: 10.1016/j.cell.2013.10.028 View journal details
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