ATP, cyclic AMP, and magnesium increase the affinity of rat striatal tyrosine hydroxylase for its cofactor.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 72 ·No. 8 ·1975-08-00 ·Pages 2955-8

Lovenberg W, Bruckwick EA, Hanbauer I

Abstract

Treatment of rat striatal tyrosine hydroxylase [tyrosine 3-monooxygenase; L-tyrosine, tetrahydropteridine:oxygen oxidoreductase (3-hydroxylating); EC 1.14.16.2] with conditions optimal for protein phosphorylation results in the reduction of the tyrosine hydroxylase Km for the cofactor 6-methyltetrahydropterin from 0.50 mM to 0.16 mM. This reaction is dependent upon ATP, 3':5'-cAMP, and Mg++ and causes a marked decrease in the sensitivity to end-product inhibition. Other brain regions and the adrenal gland show a similar response.

MeSH Terms

Adenosine Triphosphate/pharmacology Adrenal Glands/enzymology Animals Biopterin/analogs & derivatives Brain/enzymology Corpus Striatum/enzymology Cyclic AMP/pharmacology Dopamine/pharmacology Enzyme Activation/drug effects Kinetics Magnesium/pharmacology Male Organ Specificity Protein Binding Protein Kinases/metabolism Rats Tyrosine 3-Monooxygenase/metabolism

Chemicals

Biopterin Adenosine Triphosphate Cyclic AMP Tyrosine 3-Monooxygenase Protein Kinases Magnesium Dopamine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Lovenberg W

Bruckwick E A

Hanbauer I

References (15)

15 references, click to expand

Short-term control of tyrosine hydroxylase.
Adv Biochem Psychopharmacol. 1974;12(0):135-42 PMID: 4154020
Short- and long-term regulation of tyrosine hydroxylase.
Adv Biochem Psychopharmacol. 1974;12(0):161-75 PMID: 4154019
Regulation of catecholamine synthesis in the rat brain in vitro by cyclic AMP.
Nature. 1974 Nov 8;252(5479):156-8 PMID: 4153840
Biosynthesis of tyrosine hydroxylase in rat adrenal medulla after exposure to cold.
Proc Natl Acad Sci U S A. 1974 Nov;71(11):4570-4 PMID: 4155071
Changes of kinetic constant of striatal tyrosine hydroxylase elicited by neuroleptics that impair the function of dopamine receptors.
Brain Res. 1974 Oct 25;79(3):505-9 PMID: 4153770
Regulatory properties of soluble and particulate rat brain tyrosine hydroxylase.
J Biol Chem. 1972 May 25;247(10):3114-22 PMID: 4402144
Further studies on catecholamine synthesis in the spontaneously hypertensive rat: catecholamine synthesis in the central nervous system.
Eur J Pharmacol. 1973 Apr;22(1):91-8 PMID: 4145256
Regional distribution of tyrosine hydroxylase in rat brain.
J Neurochem. 1972 Sep;19(9):2241-3 PMID: 4403688
Antipsychotic drugs and dopamine-stimulated adenylate cyclase prepared from corpus striatum of rat brain.
Proc Natl Acad Sci U S A. 1974 Jul;71(7):2915-8 PMID: 4527668
Dopamine-sensitive adenylate cyclase in mammalian brain: a possible site of action of antipsychotic drugs.
Proc Natl Acad Sci U S A. 1974 Apr;71(4):1113-7 PMID: 4151517
Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain, and its similarity to the "dopamine receptor".
Proc Natl Acad Sci U S A. 1972 Aug;69(8):2145-9 PMID: 4403305
The stimulation of partially purified bovine caudate tyrosine hydroxylase by phosphatidyl-L-serine.
Biochem Biophys Res Commun. 1974 Aug 19;59(4):1262-70 PMID: 4153523
Allosteric activation of hypothalamic tyrosine hydroxylase by ions and sulphated mucopolysaccharides.
J Neurochem. 1972 Jan;19(1):131-7 PMID: 4257948
Early and selective increase in brain dopamine levels after axotomy.
Experientia. 1972 Mar 15;28(3):300-2 PMID: 4554667
Inhibitors of purified beef adrenal tyrosine hydroxylase.
Biochem Pharmacol. 1965 May;14(5):837-45 PMID: 5840732

Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.72.8.2955

Published

1975-08-00

Pages

2955-8

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC432897

Subset

External Links

PubMed source DOI: 10.1073/pnas.72.8.2955 PMC Full Text View journal details

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ATP, cyclic AMP, and magnesium increase the affinity of rat striatal tyrosine hydroxylase for its cofactor.

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