| GeneLibs

题目:: B Cells Promote Th1- Skewed NKT Cell Response by CD1d-TCR Interaction.
作者:: Shin(Jung Hoon),Park(Se-Ho)
状态:: 发布时间2013-11-07 , 更新时间 2013-11-12
期刊:: Immune Netw
摘要:: CD1d expressing dendritic cells (DCs) are good glyco-lipid antigen presenting cells for NKT cells. However, resting B cells are very weak stimulators for NKT cells. Although α-galactosylceramide (α-GalCer) loaded B cells can activate NKT cells, it is not well defined whether B cells interfere NKT cell stimulating activity of DCs. Unexpectedly, we found in this study that B cells can promote Th1-skewed NKT cell response, which means a increased level of IFN-γ by NKT cells, concomitant with a decreased level of IL-4, in the circumstance of co-culture of DCs and B Cells. Remarkably, the response promoted by B cells was dependent on CD1d expression of B cells.
语言:: eng
DOI:

文献库文献相关信息