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PMID: 2419583 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Differential susceptibility to the acquired immunodeficiency syndrome retrovirus in cloned cells of human leukemic T-cell line Molt-4.

Journal of virology ·Vol. 57 ·No. 3 ·1986-03-00 ·Pages 1159-62

Kikukawa R, Koyanagi Y, Harada S, Kobayashi N, Hatanaka M, Yamamoto N

Abstract

Cells of human leukemic T-cell line Molt-4 which were cloned in soft agarose from individual colonies were analyzed for the cytopathic effect and viral antigen expression after human T-cell lymphotropic virus type III infection. The induction of cytopathic effect and viral antigens by the infection varied significantly among the different cell clones. These clones did not show significant differences in the amount of OKT-4 antigen, a possible surface receptor for acquired immunodeficiency syndrome virus. Moreover, the virus-producing ability and the susceptibility to the virus of each clone appeared to be separable.

MeSH Terms
Acquired Immunodeficiency Syndrome/immunology Antigens, Viral/analysis,biosynthesis Cell Line Clone Cells Cytopathogenic Effect, Viral Deltaretrovirus/immunology Humans Leukemia/immunology RNA-Directed DNA Polymerase/analysis
Chemicals
Antigens, Viral RNA-Directed DNA Polymerase
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Kikukawa R
Koyanagi Y
Harada S
Kobayashi N
Hatanaka M
Yamamoto N
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.57.3.1159-1162.1986
Published
1986-03-00
Pages
1159-62
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC252852
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.57.3.1159-1162.1986 PMC Full Text View journal details
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