Synthesis of a new chemically and metabolically stable prostacyclin analogue with high and long-lasting oral activity.

Administration, Oral Animals Binding, Competitive Blood Pressure/drug effects Epoprostenol/administration & dosage,chemical synthesis,pharmacology Heart Rate/drug effects Humans Iloprost In Vitro Techniques Platelet Aggregation/drug effects Rats Receptors, Epoprostenol Receptors, Prostaglandin/metabolism

Receptors, Epoprostenol Receptors, Prostaglandin Epoprostenol Iloprost cicaprost