Agents that elevate platelet cAMP stimulate the formation of phosphatidylinositol 4-phosphate in intact human platelets.

FEBS letters ·Vol. 195 ·No. 1-2 ·1986-01-20 ·Pages 115-8

de Chaffoy de Courcelles D, Roevens P, van Belle H

Abstract

The present study investigates the effect of compounds that are known to elevate cAMP on the phospholipid metabolism of platelets. Prostaglandin E1, forskolin and isobutylmethylxanthine induce an increase in [32P]-phosphatidylinositol 4-phosphate (PIP) in platelets prelabelled with [32P]orthophosphate. Possible roles of this phenomenon are discussed in view of the inhibitory effect of cAMP elevation on platelet activation.

MeSH Terms

1-Methyl-3-isobutylxanthine/pharmacology Alprostadil/pharmacology Blood Platelets/metabolism Colforsin/pharmacology Cyclic AMP/physiology Humans In Vitro Techniques Phosphatidylinositol Phosphates Phosphatidylinositols/biosynthesis

Chemicals

Phosphatidylinositol Phosphates Phosphatidylinositols phosphatidylinositol 4-phosphate Colforsin Cyclic AMP Alprostadil 1-Methyl-3-isobutylxanthine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

de Chaffoy de Courcelles D

Roevens P

van Belle H

Article Info

Journal

FEBS letters

Abbr.

FEBS Lett

ISSN

0014-5793

DOI

10.1016/0014-5793(86)80142-9

Published

1986-01-20

Pages

115-8

Language

English

Region

England

NLM ID

0155157

Subset

External Links

PubMed source DOI: 10.1016/0014-5793(86)80142-9 View journal details

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Agents that elevate platelet cAMP stimulate the formation of phosphatidylinositol 4-phosphate in intact human platelets.

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