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PMID: 2416779 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Serum vitamin D-binding protein is a third member of the albumin and alpha fetoprotein gene family.

The Journal of clinical investigation ·Vol. 76 ·No. 6 ·1985-12-00 ·Pages 2420-4

Cooke NE, David EV

Abstract

A near full-length cDNA encoding the human vitamin D-binding protein (hDBP) was isolated from a human liver mRNA expression library. Complete sequence analysis of this clone predicts the full-length amino acid sequence of the pre-hDBP. Comparison of the sequence of the hDBP mRNA and protein to existing protein and nucleic acid data banks demonstrates a strong and highly characteristic homology of the hDBP with human albumin (hALB) and human alpha-fetoprotein (hAFP). Based upon this structural comparison, we establish that DBP is a member of the ALB and AFP gene family.

MeSH Terms
Amino Acid Sequence Base Sequence Cysteine DNA/genetics Humans Protein Conformation Sequence Homology, Nucleic Acid Serum Albumin/genetics Vitamin D-Binding Protein/genetics alpha-Fetoproteins/genetics
Chemicals
Serum Albumin Vitamin D-Binding Protein alpha-Fetoproteins DNA Cysteine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Cooke N E
David E V
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33 references, click to expand
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI112256
Published
1985-12-00
Pages
2420-4
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC424397
Subset
IM
Grants
NIGMS NIH HHS · R01GM32035 · United States
Databases
GENBANK
M12654
External Links
PubMed source DOI: 10.1172/JCI112256 PMC Full Text View journal details
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