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PMID: 2415371 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Calcitonin gene-related peptide is a potent inhibitor of substance P degradation.

European journal of pharmacology ·Vol. 115 ·No. 2-3 ·1985-09-24 ·Pages 309-11

Le Greves P, Nyberg F, Terenius L, Hökfelt T

Abstract

Calcitonin gene-related peptide (CGRP) was found to potently inhibit a substance P endopeptidase isolated from human CSF. CGRP potentiated substance P irritant actions; a possible mechanism is interaction for a common metabolic step. Somatostatin is another peptide capable of competing with substance P endopeptidase.

MeSH Terms
Calcitonin Gene-Related Peptide Humans Kinetics Nerve Tissue Proteins/pharmacology Peptide Fragments/cerebrospinal fluid Somatostatin/pharmacology Spinal Cord/metabolism Substance P/antagonists & inhibitors,cerebrospinal fluid,metabolism Vasopressins/pharmacology
Chemicals
Nerve Tissue Proteins Peptide Fragments Vasopressins Substance P Somatostatin substance P (1-7) Calcitonin Gene-Related Peptide
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Le Greves P
Nyberg F
Terenius L
Hökfelt T
Article Info
Journal
European journal of pharmacology
Abbr.
Eur J Pharmacol
ISSN
0014-2999
DOI
10.1016/0014-2999(85)90706-x
Published
1985-09-24
Pages
309-11
Language
English
Region
Netherlands
NLM ID
1254354
Subset
IM
External Links
PubMed source DOI: 10.1016/0014-2999(85)90706-x View journal details
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