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题目:: [Role of Follicular helper CD4 T cells in HIV/SIV infection].
作者:: Yamamoto(Takuya)
状态:: 发布时间2013-10-24 , 更新时间 2015-11-19
期刊:: Uirusu
摘要:: Follicular CD4 T helper (TFH) cells promote the survival, isotype switching and generation of high affinity memory B cells and plasma cells. There are numerous reports regarding the dysfunction of B cell mediated immune responses, the lack of memory CD4 T cells and the dysfunction of HIV specific CD4 T cells in SIV/HIV infection. During chronic SIV/HIV infection, TFH cell accumulation may drive B cell dysfunction and become a major HIV reservoir. In this review, we discuss the relationship between TFH cells and B cells in SIV/HIV infection.
语言:: jpn
DOI:

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