| GeneLibs

题目:: A 3D in vitro model reveals differences in the astrocyte response elicited by potential stem cell therapies for CNS injury.
作者:: East(Emma),Johns(Noémie),Georgiou(Melanie),Golding(Jon P),Loughlin(A Jane),Kingham(Paul J),Phillips(James B)
状态:: 发布时间2013-10-23 , 更新时间 2016-11-22
期刊:: Regen Med
摘要:: This study aimed to develop a 3D culture model to test the extent to which transplanted stem cells modulate astrocyte reactivity, where exacerbated glial cell activation could be detrimental to CNS repair success.,The reactivity of rat astrocytes to bone marrow mesenchymal stem cells, neural crest stem cells (NCSCs) and differentiated adipose-derived stem cells was assessed after 5 days. Schwann cells were used as a positive control.,NCSCs and differentiated Schwann cell-like adipose-derived stem cells did not increase astrocyte reactivity. Highly reactive responses to bone marrow mesenchymal stem cells and Schwann cells were equivalent.,This approach can screen therapeutic cells prior to in vivo testing, allowing cells likely to trigger a substantial astrocyte response to be identified at an early stage. NCSCs and differentiated Schwann cell-like adipose-derived stem cells may be useful in treating CNS damage without increasing astrogliosis.
语言:: eng
DOI:

文献库文献相关信息