| GeneLibs

题目:: MicroRNA targets autophagy in pancreatic cancer cells during cancer therapy.
作者:: Wang(Peng),Zhang(Li),Chen(Zhen),Meng(Zhiqiang)
状态:: 发布时间2013-12-10 , 更新时间 2016-11-28
期刊:: Autophagy
摘要:: The therapeutic outcome of pancreatic cancer is generally poor due to the inherent or acquired resistance of cancer cells to treatment. Pancreatic cancer cells have higher basal autophagy levels than other cancer cell types, which may correlate with their nonresponsiveness to the available cancer therapy. Therefore, understanding the mechanisms behind autophagy activation in pancreatic cancer cells may ultimately improve therapeutic outcomes. Here we demonstrated that MIR23B is a potent inhibitor of autophagy. MIR23B targets the 3?UTR of the autophagy-related gene ATG12, thereby decreasing autophagic activity and ultimately promoting radiation-induced pancreatic cancer cell death. Thus, our study clarified some of the underlying molecular mechanisms of activated autophagy in response to cancer therapy in pancreatic cancer.
语言:: eng
DOI:: 10.4161/auto.26463

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