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题目:: Bone marrow-derived myofibroblasts promote colon tumorigenesis through the IL-6/JAK2/STAT3 pathway.
作者:: Zhu(Liming),Cheng(Xiaojiao),Ding(Yanfei),Shi(Jindong),Jin(Huanyu),Wang(Hong),Wu(Yunlin),Ye(Jing),Lu(Yiming),Wang(Timothy C),Yang(Chung S),Tu(Shui Ping)
状态:: 发布时间2013-12-27 , 更新时间 2016-10-19
期刊:: Cancer Lett
摘要:: Bone marrow-derived myofibroblasts (BMFs) have been shown to promote tumor growth. Here, we found that BMFs or BMF conditioned medium (BMF-CM) induced cancer stem cell-like sphere formation of colon cancer cells. The co-cultured BMFs, but not co-cultured cancer cells, expressed higher levels of IL-6 than BMFs or cancer cells cultured alone. Anti-mouse IL-6 neutralizing antibody, JAK2 inhibitors and STAT3 knockdown in mouse cancer cells reduced BMF- and BMF-CM-induced sphere formation of colon cancer cells. When co-injected, BMFs significantly enhanced tumorigenesis of colon cancer cells in mice. Our results demonstrate that BMFs promote tumorigenesis via the activation of the IL-6/JAK2/STAT3 pathway.
语言:: eng
DOI:: 10.1016/j.canlet.2013.09.017

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