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PMID: 2413934 Published · ppublish English Journal Article

[3H]-tetracaine binding on rat synaptosomes and sodium channels.

British journal of pharmacology ·Vol. 86 ·No. 1 ·1985-09-00 ·Pages 125-9

Grima M, Schwartz J, Spach MO, Velly J

Abstract

[3H]-tetracaine binding was studied in a rat synaptosomal preparation. [3H]-tetracaine bound to a single class of binding sites with a mean KD of 188 +/- 28 nM and a mean maximal binding capacity of 13 +/- 0.7 pmol mg-1 protein. [3H]-tetracaine binding was inhibited by tetracaine, procaine and by beta-adrenoceptor blocking agents which possess local anaesthetic properties. [3H]-tetracaine binding was not modified by neurotoxins interacting specifically with the sodium channels.

MeSH Terms
Adrenergic beta-Antagonists/pharmacology Anesthetics, Local/pharmacology Animals Binding, Competitive/drug effects In Vitro Techniques Ion Channels/drug effects,metabolism Kinetics Male Neurotoxins/pharmacology Rats Rats, Inbred Strains Synaptosomes/metabolism Tetracaine/metabolism
Chemicals
Adrenergic beta-Antagonists Anesthetics, Local Ion Channels Neurotoxins Tetracaine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Grima M
Schwartz J
Spach M O
Velly J
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22 references, click to expand
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Article Info
Journal
British journal of pharmacology
Abbr.
Br J Pharmacol
ISSN
0007-1188
DOI
10.1111/j.1476-5381.1985.tb09442.x
Published
1985-09-00
Pages
125-9
Language
English
Region
England
NLM ID
7502536
PMCID
PMC1916878
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1476-5381.1985.tb09442.x PMC Full Text View journal details
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