| GeneLibs

题目:: Identification of a new stromal cell type involved in the regulation of inflamed B cell follicles.
作者:: Mionnet(Cyrille),Mondor(Isabelle),Jorquera(Audrey),Loosveld(Marie),Maurizio(Julien),Arcangeli(Marie-Laure),Ruddle(Nancy H),Nowak(Jonathan),Aurrand-Lions(Michel),Luche(Hervé),Bajénoff(Marc)
状态:: 发布时间2013-10-16 , 更新时间 2016-10-19
期刊:: PLoS Biol
摘要:: Lymph node (LN) stromal cells provide survival signals and adhesive substrata to lymphocytes. During an immune response, B cell follicles enlarge, questioning how LN stromal cells manage these cellular demands. Herein, we used a murine fate mapping system to describe a new stromal cell type that resides in the T cell zone of resting LNs. We demonstrated that upon inflammation, B cell follicles progressively trespassed into the adjacent T cell zone and surrounded and converted these stromal cells into CXCL13 secreting cells that in return delineated the new boundaries of the growing follicle. Acute B cell ablation in inflamed LNs abolished CXCL13 secretion in these cells, while LT-β deficiency in B cells drastically affected this conversion. Altogether, we reveal the existence of a dormant stromal cell subset that can be functionally awakened by B cells to delineate the transient boundaries of their expanding territories upon inflammation.
语言:: eng
DOI:

文献库文献相关信息