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题目:: Targeting receptor tyrosine kinases in HER2-negative breast cancer.
作者:: Anandappa(Gayathri),Turner(Nicholas C)
状态:: 发布时间2013-11-15 , 更新时间 2016-11-25
期刊:: Curr Opin Oncol
摘要:: The targeting of receptor tyrosine kinases (RTKs) has been a major area for breast cancer therapy, exemplified by the targeting of HER2-amplified breast cancer.,We review the data on the activation of RTKs in HER2-negative breast cancer, and discuss the clinical translational challenge of identifying cancers that are reliant on a specific kinase for growth and survival. Substantial evidence suggests that subsets of breast cancer may be reliant on specific kinases, and that this could be exploited therapeutically. The heterogeneity of breast cancer, however, and the potential for adaptive switching between RTKs after inhibition of a single RTK, present challenges to targeting individual RTKs in the clinic,Targeting of RTKs in HER2-negative breast cancer presents a major therapeutic opportunity in breast cancer, although robust selection strategies will be required to identify cancers with activation of specific RTKs if this potential is to be realized.
语言:: eng
DOI:: 10.1097/CCO.0000000000000021

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