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PMID: 2409209 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Distinct recognition phenotypes exist for T cell clones specific for small peptide regions of proteins. Implications for the mechanisms underlying major histocompatibility complex-restricted antigen recognition and clonal deletion models of immune response gene defects.

The Journal of experimental medicine ·Vol. 162 ·No. 1 ·1985-07-01 ·Pages 332-45

Shastri N, Oki A, Miller A, Sercarz EE

Abstract

Using synthetic peptides as antigens, it was found that T cell clones of a given haplotype specific for 13-16 amino acid peptides could be clearly distinguished by the varied influence of amino acid substitutions on recognition. This was true for different antigenic determinants within peptides 81-96 and 74-86 of hen egg-white lysozyme, recognized in the context of the I-Ab and I-Ak molecules, respectively. Considerable complexity was demonstrated in the induced T cell repertoire specific for apparently single determinants, which implies that diversity of T cell recognition approaches that for B cells. The implications of the degeneracy of T cell recognition are discussed in the context of mechanisms through which Ia molecules restrict recognition and theories of Ir gene defects.

MeSH Terms

Animals Clone Cells/immunology Epitopes/immunology Female Genes, MHC Class II Histocompatibility Antigens Class II/immunology Major Histocompatibility Complex Male Mice Mice, Inbred Strains Models, Biological Muramidase/immunology Peptides/immunology Phenotype T-Lymphocytes/immunology

Chemicals

Epitopes Histocompatibility Antigens Class II Peptides Muramidase

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Shastri N

Oki A

Miller A

Sercarz E E

References (32)

32 references, click to expand

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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.162.1.332

Published

1985-07-01

Pages

332-45

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2187680

Subset

Grants

NIAID NIH HHS · AI-11183 · United States

NCI NIH HHS · CA-24442 · United States

External Links

PubMed source DOI: 10.1084/jem.162.1.332 PMC Full Text View journal details

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Distinct recognition phenotypes exist for T cell clones specific for small peptide regions of proteins. Implications for the mechanisms underlying major histocompatibility complex-restricted antigen recognition and clonal deletion models of immune response gene defects.

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