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PMID: 2406566 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The c-myc-regulated gene mrl encodes plasminogen activator inhibitor 1.

Molecular and cellular biology ·Vol. 10 ·No. 3 ·1990-03-00 ·Pages 1265-9

Prendergast GC, Diamond LE, Dahl D, Cole MD

Abstract

The DNA sequence of the c-myc-regulated gene mrl (G. C. Prendergast and M. D. Cole, Mol. Cell. Biol. 9:124-134, 1989) reveals that it encodes plasminogen activator inhibitor 1 (PAI-1), a regulator of extracellular proteolysis. Comparison of the human and mouse PAI-1 promoters and cDNA 3' noncoding regions revealed several highly conserved sequence domains, potential targets for c-myc and other factors influencing PAI-1 expression. We discuss possible roles for PAI-1 in normal and neoplastic cell growth control.

MeSH Terms
Animals Base Sequence DNA/genetics Genes Mice Molecular Sequence Data Promoter Regions, Genetic Proto-Oncogene Proteins/genetics Proto-Oncogene Proteins c-myc Sequence Homology, Nucleic Acid alpha-2-Antiplasmin/metabolism
Chemicals
Proto-Oncogene Proteins Proto-Oncogene Proteins c-myc alpha-2-Antiplasmin DNA
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Prendergast G C
Department of Biology, Lewis Thomas Laboratory, Princeton University, New Jersey 08544-1014.
Diamond L E
Dahl D
Cole M D
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.10.3.1265-1269.1990
Published
1990-03-00
Pages
1265-9
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC361018
Subset
IM
Databases
GENBANK
M33960, M33961
External Links
PubMed source DOI: 10.1128/mcb.10.3.1265-1269.1990 PMC Full Text View journal details
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