Abstract
A question remaining to be answered about RecA protein function concerns the role of ATP hydrolysis during the DNA-strand-exchange reaction. In this paper we describe the formation of joint molecules in the absence of ATP hydrolysis, using adenosine 5'-[gamma-thio]triphosphate (ATP[gamma S]) as nucleotide cofactor. Upon the addition of double-stranded DNA, the ATP[gamma S]-RecA protein-single-stranded DNA presynaptic complexes can form homologously paired molecules that are stable after deproteinization. Formation of these joint molecules requires both homology and a free homologous end, suggesting that they are plectonemic in nature. This reaction is very sensitive to magnesium ion concentration, with a maximum rate and extent observed at 4-5 mM magnesium acetate. Under these conditions, the average length of heteroduplex DNA within the joint molecules is 2.4-3.4 kilobase pairs. Thus, RecA protein can form extensive regions of heteroduplex DNA in the presence of ATP[gamma S], suggesting that homologous pairing and the exchange of the DNA molecules can occur without ATP hydrolysis. A model for the RecA protein-catalyzed DNA-strand-exchange reaction that incorporates these results and its relevance to the mechanisms of eukaryotic recombinases are presented.
MeSH Terms
Acetates/pharmacology
Acetic Acid
Adenosine Triphosphate/analogs & derivatives,metabolism
DNA, Bacterial/metabolism
Escherichia coli/metabolism
Hydrolysis
Kinetics
Models, Structural
Nucleic Acid Heteroduplexes/metabolism
Rec A Recombinases/metabolism
Chemicals
Acetates
DNA, Bacterial
Nucleic Acid Heteroduplexes
adenosine 5'-O-(3-thiotriphosphate)
Adenosine Triphosphate
Rec A Recombinases
Acetic Acid
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Menetski J P
Department of Molecular Biology, Northwestern University Medical School, Chicago, IL 60611.
Bear D G
Kowalczykowski S C
References (23)
23 references, click to expand
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