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PMID: 2403531 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Tumor necrosis factor production by human macrophages stimulated in vitro by Plasmodium falciparum.

Infection and immunity ·Vol. 58 ·No. 1 ·1990-01-00 ·Pages 214-6

Picot S, Peyron F, Vuillez JP, Barbe G, Marsh K, Ambroise-Thomas P

Abstract

Production of tumor necrosis factor by human macrophages may be induced in vitro by cytoadherent and noncytoadherent strains of Plasmodium falciparum, with an optimal ratio of one to three parasitized erythrocytes per macrophage. Centrifuged and heated crude culture supernatants have the same effect, thus showing the existence of a thermostable soluble factor able to induce this expression. In vitro kinetic experiments have shown that the secretion of tumor necrosis factor appears early, with a maximal peak at 8 h.

MeSH Terms

Animals Erythrocytes/parasitology Immunity, Cellular In Vitro Techniques Macrophages/metabolism Plasmodium falciparum/immunology Tumor Necrosis Factor-alpha/biosynthesis

Chemicals

Tumor Necrosis Factor-alpha

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Picot S

Unité URA 1344 Centre National de la Recherche Scientifique, Hôpital A. Michallon, Grenoble, France.

Peyron F

Vuillez J P

Barbe G

Marsh K

Ambroise-Thomas P

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27 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.58.1.214-216.1990

Published

1990-01-00

Pages

214-6

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC258431

Subset

External Links

PubMed source DOI: 10.1128/iai.58.1.214-216.1990 PMC Full Text View journal details

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Tumor necrosis factor production by human macrophages stimulated in vitro by Plasmodium falciparum.

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