RASAL2: wrestling in the combat of Ras activation.
作者:
Shen(Jia),Wang(Yan),Hung(Mien-Chie)
状态:
发布时间2013-09-13
, 更新时间 2013-09-13
期刊:
Cancer Cell
摘要:
Oncogenic activation of Ras proteins due to missense mutations is frequently detected in human cancers but rarely in breast cancer. In this issue of Cancer Cell, McLaughlin and colleagues report that ablation of the GasGAP gene, RASAL2, is an alternative mechanism by which Ras becomes activated in breast cancer.