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题目:: Breaking the canon: indirect regulation of Wnt signaling in mammary stem cells by MMP3.
作者:: LaBarge(Mark A)
状态:: 发布时间2013-09-09 , 更新时间 2016-05-18
期刊:: Cell Stem Cell
摘要:: Matrix metalloproteases promote tumor cell invasion, epithelial-to-mesenchymal transitions, and metastases, but whether they directly regulate stem cells is unknown. In this issue of Cell Stem Cell, Kessenbrock et al. (2013) now show that MMP3, independent of its proteolytic activity, regulates murine mammary stem cells by sequestering noncanonical Wnt signaling ligands, which has implications for breast cancer pathogenesis.
语言:: eng
DOI:: 10.1016/j.stem.2013.08.008

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