Sinister symbiosis: pathological hematopoietic-stromal interactions in CML.
作者:
Mullally(Ann),Ebert(Benjamin L)
状态:
发布时间2013-09-09
, 更新时间 2016-10-25
期刊:
Cell Stem Cell
摘要:
The impact of myeloid malignancies on the nonhematopoietic components of the bone marrow remains poorly understood. In this issue of Cell Stem Cell, Schepers et al. (2013) describe how malignant myeloid cells alter the endosteal hematopoietic stem cell (HSC) niche, resulting in the expansion of osteoblastic lineage cells that preferentially support malignant HSCs.