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PMID: 23924659 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Type 2 innate lymphoid cells constitutively express arginase-I in the naive and inflamed lung.

Journal of leukocyte biology ·Vol. 94 ·No. 5 ·2013-11-00 ·Pages 877-84

Bando JK, Nussbaum JC, Liang HE, Locksley RM

Abstract

Arg1 is produced by AAMs and is proposed to have a regulatory role during asthma and allergic inflammation. Here, we use an Arg1 reporter mouse to identify additional cellular sources of the enzyme in the lung. We demonstrate that ILC2s express Arg1 at rest and during infection with the migratory helminth Nippostrongylus brasiliensis. In contrast to AAMs, which express Arg1 following IL-4/IL-13-mediated STAT6 activation, ILC2s constitutively express the enzyme in a STAT6-independent manner. Although ILC2s deficient in the IL-33R subunit T1/ST2 maintain Arg1 expression, IL-33 can regulate total lung Arg1 by expanding the ILC2 population and by activating macrophages indirectly via STAT6. Finally, we find that ILC2 Arg1 does not mediate ILC2 accumulation, ILC2 production of IL-5 and IL-13, or collagen production during N. brasiliensis infection. Thus, ILC2s are a novel source of Arg1 in resting tissue and during allergic inflammation.

Keywords
Arg1-YFP ILC2 Nippostrongylus brasiliensis Yarg alternatively activated macrophages
MeSH Terms
Animals Arginase/genetics,physiology Cytokines/biosynthesis Immunity, Innate Interleukin-33 Interleukins/pharmacology Lung/immunology Lymphocytes/enzymology Mice Mice, Inbred C57BL Nippostrongylus Pneumonia/immunology STAT6 Transcription Factor/physiology Strongylida Infections/immunology
Chemicals
Cytokines IL33 protein, human Interleukin-33 Interleukins STAT6 Transcription Factor Stat6 protein, mouse Arg1 protein, mouse Arginase
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Bando Jennifer K
1.UCSF, 513 Parnassus Ave., S-1004, San Francisco, CA 94143, USA. locksley@medicine.ucsf.edu.
Nussbaum Jesse C
Liang Hong-Erh
Locksley Richard M
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Article Info
Journal
Journal of leukocyte biology
Abbr.
J Leukoc Biol
ISSN
1938-3673
Published
2013-11-00
Epub
2013-00-07
Pages
877-84
Language
English
Region
United States
NLM ID
8405628
PMCID
PMC3800063
Subset
IM
Grants
NIDDK NIH HHS · P30 DK063720 · United States
NHLBI NIH HHS · P01 HL107202 · United States
Howard Hughes Medical Institute · United States
NIAID NIH HHS · R01 AI026918 · United States
NIAID NIH HHS · T32 AI007641 · United States
NIAID NIH HHS · R37 AI26918 · United States
NHLBI NIH HHS · PPG HL107202 · United States
NIAID NIH HHS · R01 AI030663 · United States
NIAID NIH HHS · R01 AI30663 · United States
NIAID NIH HHS · R37 AI026918 · United States
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