Abstract
Arg1 is produced by AAMs and is proposed to have a regulatory role during asthma and allergic inflammation. Here, we use an Arg1 reporter mouse to identify additional cellular sources of the enzyme in the lung. We demonstrate that ILC2s express Arg1 at rest and during infection with the migratory helminth Nippostrongylus brasiliensis. In contrast to AAMs, which express Arg1 following IL-4/IL-13-mediated STAT6 activation, ILC2s constitutively express the enzyme in a STAT6-independent manner. Although ILC2s deficient in the IL-33R subunit T1/ST2 maintain Arg1 expression, IL-33 can regulate total lung Arg1 by expanding the ILC2 population and by activating macrophages indirectly via STAT6. Finally, we find that ILC2 Arg1 does not mediate ILC2 accumulation, ILC2 production of IL-5 and IL-13, or collagen production during N. brasiliensis infection. Thus, ILC2s are a novel source of Arg1 in resting tissue and during allergic inflammation.
Keywords
Arg1-YFP
ILC2
Nippostrongylus brasiliensis
Yarg
alternatively activated macrophages
MeSH Terms
Animals
Arginase/genetics,physiology
Cytokines/biosynthesis
Immunity, Innate
Interleukin-33
Interleukins/pharmacology
Lung/immunology
Lymphocytes/enzymology
Mice
Mice, Inbred C57BL
Nippostrongylus
Pneumonia/immunology
STAT6 Transcription Factor/physiology
Strongylida Infections/immunology
Chemicals
Cytokines
IL33 protein, human
Interleukin-33
Interleukins
STAT6 Transcription Factor
Stat6 protein, mouse
Arg1 protein, mouse
Arginase
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Bando Jennifer K
1.UCSF, 513 Parnassus Ave., S-1004, San Francisco, CA 94143, USA. locksley@medicine.ucsf.edu.
Nussbaum Jesse C
Liang Hong-Erh
Locksley Richard M
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