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PMID: 23870665 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Emerging roles of E3 ubiquitin ligases in autophagy.

Trends in biochemical sciences ·Vol. 38 ·No. 9 ·2013-09-00 ·Pages 453-60

Kuang E, Qi J, Ronai Z

Abstract

Autophagy is an evolutionarily conserved intracellular catabolic process that delivers cytoplasmic components to lysosomes for degradation and recycling. Although originally considered to be a non-selective pathway, it is now recognized that autophagy is involved in selective processes, including the turnover of organelles, removal of protein aggregates, and elimination of intracellular pathogens. This specificity implies that cargo recognition and processing by the autophagy machinery are tightly regulated processes. In support of this, various forms of post-translational modification have been implicated in the regulation of autophagy, one of which is the ubiquitin-proteasome system. Here we review current understanding of the role of ubiquitylation in the control of autophagy.

Keywords
RNF5 autophagy parkin proteasome ubiquitin ligase
MeSH Terms
Animals Autophagy/genetics,physiology Humans Ubiquitin-Protein Ligases/genetics,metabolism
Chemicals
Ubiquitin-Protein Ligases parkin protein
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kuang Ersheng
Signal Transduction Program, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA. kuangersh@mail.sysu.edu.cn
Qi Jianfei
Ronai Ze'ev
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Article Info
Journal
Trends in biochemical sciences
Abbr.
Trends Biochem Sci
ISSN
0968-0004
DOI
10.1016/j.tibs.2013.06.008
Email
kuangersh@mail.sysu.edu.cn
Published
2013-09-00
Epub
2013-00-16
Pages
453-60
Language
English
Region
England
NLM ID
7610674
PMCID
PMC3771342
Subset
IM
Grants
NCI NIH HHS · R01 CA097105 · United States
NCI NIH HHS · R00 CA154888 · United States
NCI NIH HHS · CA154888 · United States
NCI NIH HHS · CA097105 · United States
NCI NIH HHS · K99 CA154888 · United States
External Links
PubMed source DOI: 10.1016/j.tibs.2013.06.008 PMC Full Text View journal details
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