Evidence for two Ca2(+)-mobilizing purinoceptors on rat hepatocytes.
Aequorin measurements of cytosolic free Ca2+ in single rat hepatocytes show that ADP and ATP, thought to act through the same P2Y purinoceptor, elicited very different responses in the majority of cells tested. ADP invariably induced transients of short duration (approx. 9 s), whereas ATP induced either similar transients or transients with a much longer duration (approx. 49 s). We explain this variability in terms of two separate purinoceptors on rat hepatocytes, one of which responds to either ATP or ADP to generate free-Ca2+ transients of short duration, and the other responds to ATP only, with transients of longer duration.
18 references, click to expand
-
Single cell measurements in research on calcium-mobilising purinoceptors.J Recept Res. 1988;8(1-4):481-91 PMID: 3385690
-
P2-purinergic receptors are coupled to two signal transduction systems leading to inhibition of cAMP generation and to production of inositol trisphosphate in rat hepatocytes.J Biol Chem. 1987 Oct 5;262(28):13483-90 PMID: 2443492
-
Spatial and temporal aspects of cell signalling.Philos Trans R Soc Lond B Biol Sci. 1988 Jul 26;320(1199):325-43 PMID: 2906142
-
Calcium oscillations in non-excitable cells.Trends Neurosci. 1989 Feb;12(2):43-6 PMID: 2469208
-
ATP-induced calcium mobilization in human neutrophils.Biochim Biophys Acta. 1989 Jun 15;1012(1):103-6 PMID: 2499355
-
Extracellular ATP induces the release of calcium from intracellular stores without the activation of protein kinase C in Swiss 3T6 mouse fibroblasts.Proc Natl Acad Sci U S A. 1989 Jun;86(12):4530-4 PMID: 2734303
-
Characterization of cytosolic calcium oscillations induced by phenylephrine and vasopressin in single fura-2-loaded hepatocytes.J Biol Chem. 1989 Oct 15;264(29):17131-41 PMID: 2793847
-
Two distinct receptors for ATP can be distinguished in Swiss 3T6 mouse fibroblasts by their desensitization.Biochem Biophys Res Commun. 1989 Oct 31;164(2):706-13 PMID: 2818584
-
Modulation of free Ca oscillations in single hepatocytes by changes in extracellular K+, Na+ and Ca2+.Cell Calcium. 1990 May;11(5):353-60 PMID: 2364412
-
Purification of (Ca2+-Mg2+)-ATPase from rat liver plasma membranes.J Biol Chem. 1984 Mar 10;259(5):3016-20 PMID: 6142050
-
Phorbol ester and sperm activate mouse oocytes by inducing sustained oscillations in cell Ca2+.Nature. 1985 Aug 8-14;316(6028):541-2 PMID: 4033751
-
Is there a basis for distinguishing two types of P2-purinoceptor?Gen Pharmacol. 1985;16(5):433-40 PMID: 2996968
-
Repetitive transient rises in cytoplasmic free calcium in hormone-stimulated hepatocytes.Nature. 1986 Feb 13-19;319(6054):600-2 PMID: 3945348
-
Extracellular ATP: effects, sources and fate.Biochem J. 1986 Jan 15;233(2):309-19 PMID: 3006665
-
Characterization of the liver P2-purinoceptor involved in the activation of glycogen phosphorylase.Biochem J. 1986 Dec 1;240(2):367-71 PMID: 3814090
-
Agonist-induced oscillations in cytoplasmic free calcium concentration in single rat hepatocytes.Cell Calcium. 1987 Feb;8(1):79-100 PMID: 3829123
-
A novel receptor-operated Ca2+-permeable channel activated by ATP in smooth muscle.Nature. 1987 Jul 16-22;328(6127):275-8 PMID: 2439921
-
Two Ca2+-dependent ATPases in rat liver plasma membrane. The previously purified (Ca2+-Mg2+)-ATPase is not a Ca2+-pump but an ecto-ATPase.J Biol Chem. 1988 Sep 5;263(25):12253-8 PMID: 2457581
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: product@genelibs.com
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
