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PMID: 238554 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Mechanism of action of local anaesthetic agents and biotoxins.

British journal of anaesthesia ·Vol. 47 suppl ·1975-02-00 ·Pages 191-8

Ritchie JM

Abstract

Four current theories for the mechanism of action of local anaesthetics are that these drugs: (1) interfere with some chemical, such as acetylcholine, that is involved in nervous conduction; (2) alter the density of fixed charges on the surface of the membrane; (3) cause an expansion of some volume of membrane that is critical for conduction; and (4) react with some specific receptor in the nerve membrane. The first theory fails for lack of evidence that acetylcholine is involved physiologically in conduction. The other three theories, however, all seem to apply.

MeSH Terms

Acetylcholine/antagonists & inhibitors Action Potentials/drug effects Anesthetics, Local/pharmacology Animals Benzocaine/pharmacology Binding Sites Binding, Competitive Calcium/pharmacology Cell Membrane/drug effects,metabolism Fishes Humans Hydrogen-Ion Concentration Lidocaine/analogs & derivatives Membrane Potentials/drug effects Neural Conduction/drug effects Potassium/metabolism Procaine/pharmacology Rabbits Saxitoxin/pharmacology Sodium/metabolism Structure-Activity Relationship Surface Properties Tetrodotoxin/pharmacology Toxins, Biological/pharmacology

Chemicals

Anesthetics, Local Toxins, Biological Saxitoxin Tetrodotoxin Procaine Lidocaine Sodium Acetylcholine Potassium Calcium Benzocaine

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Ritchie J M

Article Info

Journal

British journal of anaesthesia

Abbr.

Br J Anaesth

ISSN

0007-0912

Published

1975-02-00

Pages

191-8

Language

English

Region

England

NLM ID

0372541

Subset

External Links

PubMed source View journal details

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Mechanism of action of local anaesthetic agents and biotoxins.

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