| GeneLibs

题目:: Toward single cell traction microscopy within 3D collagen matrices.
作者:: Hall(Matthew S),Long(Rong),Feng(Xinzeng),Huang(Yuling),Hui(Chung-Yuen),Wu(Mingming)
状态:: 发布时间2013-09-11 , 更新时间 2016-10-19
期刊:: Exp Cell Res
摘要:: Mechanical interaction between the cell and its extracellular matrix (ECM) regulates cellular behaviors, including proliferation, differentiation, adhesion, and migration. Cells require the three-dimensional (3D) architectural support of the ECM to perform physiologically realistic functions. However, current understanding of cell-ECM and cell-cell mechanical interactions is largely derived from 2D cell traction force microscopy, in which cells are cultured on a flat substrate. 3D cell traction microscopy is emerging for mapping traction fields of single animal cells embedded in either synthetic or natively derived fibrous gels. We discuss here the development of 3D cell traction microscopy, its current limitations, and perspectives on the future of this technology. Emphasis is placed on strategies for applying 3D cell traction microscopy to individual tumor cell migration within collagen gels.
语言:: eng
DOI:

文献库文献相关信息