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题目:: The impact of molecular morphology techniques on the expert diagnosis in melanocytic skin neoplasms.
作者:: Ferrara(Gerardo),Misciali(Cosimo),Brenn(Thomas),Cerroni(Lorenzo),Kazakov(Dmitry W),Perasole(Antonio),Russo(Rosa),Ricci(Roberto),Crisman(Giuliana),Fanti(Pier Alessandro),Passarini(Beatrice),Patrizi(Annalisa)
状态:: 发布时间2013-09-25 , 更新时间 2015-11-19
期刊:: Int J Surg Pathol
摘要:: Thirteen melanocytic skin neoplasms with a consultation diagnosis by A. Bernard Ackerman were submitted to immunohistochemistry for HMB-45, Ki67, cyclin D1, e-cadherin, and p16; 9/13 cases underwent fluorescence in situ hybridization (FISH) test targeting 6p25 (RREB1), 6q23 (MYB), centromere 6 (Cep6), and 11q13 (CCND1), as well as the centromere 7 (Cep7). A "consensus diagnosis" among 3 experts was also advocated both before and after morphomolecular information. Three neoplasms with a consultation diagnosis of Spitz nevus showed at least 3 abnormal immunohistochemical patterns; 2 of these cases were also FISH-positive for CCND1 gain, but none of them had a final consensus diagnosis of melanoma. Two neoplasms with a consultation diagnosis of congenital nevus received a consensus diagnosis of melanoma. Molecular morphology techniques can highlight the atypical features of melanocytic neoplasms and support existence of a morphobiologic "spectrum": This should be mirrored in the final report by abandoning the dichotomic (benign vs malignant) diagnostic approach.
语言:: eng
DOI:: 10.1177/1066896913491323

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