Inactivation of E. coli RNA polymerase by pyridoxal 5'-phosphate: identificationof a low pKa lysine as the modified residue.

Amino Acid Sequence Amino Acids/analysis Binding Sites Borohydrides DNA-Directed RNA Polymerases/antagonists & inhibitors Escherichia coli/drug effects Hydrogen-Ion Concentration Kinetics Lysine/analysis Protein Binding Protein Conformation Pyridoxal Phosphate/pharmacology Time Factors

Amino Acids Borohydrides Pyridoxal Phosphate DNA-Directed RNA Polymerases Lysine