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PMID: 2374928 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Stimulation of phospholipase C-gamma 1 membrane association by epidermal growth factor.

Science (New York, N.Y.) ·Vol. 249 ·No. 4966 ·1990-07-20 ·Pages 296-8

Todderud G, Wahl MI, Rhee SG, Carpenter G

Abstract

Epidermal growth factor (EGF) treatment of A-431 epidermoid carcinoma cells elicited a redistribution of phospholipase C-gamma 1 (PLC-gamma 1) from a predominantly cytosolic localization to membrane fractions. The temporal coincidence of this redistribution with EGF stimulation of inositol phosphate formation and EGF increased phosphorylation of PLC-gamma 1 suggests that the membrane association of PLC-gamma 1 is a significant event in second messenger transduction.

MeSH Terms

Carcinoma, Squamous Cell Cell Line Cell Membrane/drug effects,enzymology Cytosol/enzymology Epidermal Growth Factor/pharmacology Humans Isoenzymes/metabolism Kinetics Phosphopeptides/isolation & purification Protein Binding Trypsin Type C Phospholipases/metabolism

Chemicals

Isoenzymes Phosphopeptides Epidermal Growth Factor Type C Phospholipases Trypsin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Todderud G

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146.

Wahl M I

Rhee S G

Carpenter G

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.2374928

Published

1990-07-20

Pages

296-8

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NCI NIH HHS · CA24071 · United States

NIGMS NIH HHS · GM07347 · United States

NIADDK NIH HHS · T32 AM07491 · United States

External Links

PubMed source DOI: 10.1126/science.2374928 View journal details

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Stimulation of phospholipase C-gamma 1 membrane association by epidermal growth factor.

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