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PMID: 23665896 Published · epublish English Journal Article Research Support, Non-U.S. Gov't Review

Rab27 GTPases distribute extracellular nanomaps for invasive growth and metastasis: implications for prognosis and treatment.

International journal of molecular sciences ·Vol. 14 ·No. 5 ·2013-05-10 ·Pages 9883-92

Hendrix A, De Wever O

Abstract

The Rab27 family of small GTPases regulates exocytosis of distinct vesicle types including multivesicular endosomes, which results in the release of exosomes. Exosomes are nanometer-sized membrane vesicles that enclose soluble factors such as proteins and nucleic acids within a lipid bilayer and can travel toward distant tissues to influence multiple aspects of cell behavior. In our view that tumors are endocrine organs producing exosomes, Rab27 GTPases and their effector proteins are critical determinants for invasive growth and metastasis. Rab27 proteins and their effectors may serve as prognostic biomarkers or as targets for patient-tailored therapy.

MeSH Terms
Animals Exocytosis Exosomes/metabolism,pathology Humans Neoplasm Invasiveness/diagnosis,pathology Neoplasm Metastasis/diagnosis,pathology Neoplasms/diagnosis,metabolism,pathology,therapy Prognosis rab GTP-Binding Proteins/analysis,metabolism rab27 GTP-Binding Proteins
Chemicals
rab27 GTP-Binding Proteins RAB27A protein, human Rab27B protein, human rab GTP-Binding Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hendrix An
Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium. an.hendrix@ugent.be.
De Wever Olivier
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Article Info
Journal
International journal of molecular sciences
Abbr.
Int J Mol Sci
ISSN
1422-0067
DOI
10.3390/ijms14059883
Email
an.hendrix@ugent.be
Published
2013-05-10
Epub
2013-00-10
Pages
9883-92
Language
English
Region
Switzerland
NLM ID
101092791
PMCID
PMC3676819
Subset
IM
External Links
PubMed source DOI: 10.3390/ijms14059883 PMC Full Text View journal details
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