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题目:: Single naive CD4+ T cells from a diverse repertoire produce different effector cell types during infection.
作者:: Tubo(Noah J),Pagán(Antonio J),Taylor(Justin J),Nelson(Ryan W),Linehan(Jonathan L),Ertelt(James M),Huseby(Eric S),Way(Sing Sing),Jenkins(Marc K)
状态:: 发布时间2013-05-13 , 更新时间 2016-10-19
期刊:: Cell
摘要:: A naive CD4(+) T cell population specific for a microbial peptide:major histocompatibility complex II ligand (p:MHCII) typically consists of about 100 cells, each with a different T cell receptor (TCR). Following infection, this population produces a consistent ratio of effector cells that activate microbicidal functions of macrophages or help B cells make antibodies. We studied the mechanism that underlies this division of labor by tracking the progeny of single naive T cells. Different naive cells produced distinct ratios of macrophage and B cell helpers but yielded the characteristic ratio when averaged together. The effector cell pattern produced by a given naive cell correlated with the TCR-p:MHCII dwell time or the amount of p:MHCII. Thus, the consistent production of effector cell subsets by a polyclonal population of naive cells results from averaging the diverse behaviors of individual clones, which are instructed in part by the strength of TCR signaling.
语言:: eng
DOI:

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